Picture of John Gordon

John Gordon Associate Member, Department of Veterinary Microbiology

Academic Credentials

  • BSc (Advanced), University of Saskatchewan
  • PhD, University of Saskatchewan
  • Post-Doctoral, National Institutes for Medical Research, Mill Hill, UK
  • Post-Doctoral, Harvard Medical School, Boston

Research Interests

Dr. Gordon's research interests include immunology and immunopathology. Areas of special interest and research are tolerance induction in allergy/asthma, cytokines, regulation of immune responses, therapeutic amelioration of neutrophilic inflammation - each in human and veterinary species.

  • Allergic disease: We have assessed the potential for using autologous dendritic cells to tolerize allergic airway disease/asthma in an animal model of this disease. Our data suggest that transfer of allergen-pulsed tolerogenic dendritic cells into animals with severe allergic lung disease dramatically ameliorates airway hyperresponsiveness and down-regulates its immunologic correlates. We are dissecting the mechanisms responsible for these effects. (Supported by the Canadian Institutes for Medical Research)
  • Inflammation: We have recently developed a high affinity antagonist of multiple ELR-CXC chemokines, CXCL8(3-73)K11R/G31P, that blocks the in vitro inflammatory activities expressed in pneumonic pasteurellosis and mastitis lesions. It also ameliorates neutrophilic inflammatory responses to endotoxin challenge in vivo in cattle, pigs and guinea pigs, blocking their fever and hemorrhagic responses in tandem, and antagonizes the activity the ELR-CXC chemokines (e.g., CXL8/IL-8) on human neutrophils.

For more information about Dr. Gordon's research program, please visit his website.

Publications

Books, chapters and reviews:

J.R. Gordon, Y. Ma, L. Churchman, S.A. Gordon and W. Dawicki.  2014.  Regulatory dendritic cells for immunotherapy in immunologic diseases.  Frontiers in Immunology 5: 7 (12 pp; doi: 10.3389/fimmu.2014.00007)

S.J. Reynolds, M.W. Nonnenmann, I. Basinas, M. Davidson, L. Elfman, J.R. Gordon, S. Kirychuck, S. Reed, J. Schaeffer, M. Schenker, V. Schlunssen, and T. Sigsgaard.  2013. Systematic review of respiratory health among dairy workers.  J Agromedicine 18:219-43

Research reports:

M. Khan, B. Wang, J. Wei, Y Zhang, Q. Li, X. Luan, J-W. Cheng, J.R. Gordon, F. Li, and H. Liu. CXCR1/2 antagonism with a CXCL8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumour cell proliferation and suppressing angiogenesis. Oncotarget, submitted Jan 29, 2015

D Schneberger, JR Gordon, AJ Heires, JD DeVasure, JA Boten, DJ Romberger, TA Wyatt. 2015. CXCR1/CXCR2 antagonist CXCL8(3-74)K11R/G31P blocks lung inflammation in swine barn dust-instilled mice. Pulmonary Pharmacology and Therapeutics 31:55-62

P. Novakovic, Y.Y. Huang, B. Lockerbie, F. Shahriar, J. Kelly, J.R. Gordon, D.M. Middleton, M.E. Loewen, B.A. Kidney, and E. Simko. 2015. Identification of F4ac-binding proteins of porcine milk fat globule membranes.  Canadian Journal of Veterinary Research 79:120-8

L. Li, MN Khan, Q Li, X Chen, J Wei, B. Wang, J-W Cheng, JR Gordon and F Li. 2015. G31P, CXCR1/2 inhibitor, with cisplatin inhibits the growth of mice hepatocellular carcinoma and mitigates high‑dose cisplatin-induced nephrotoxicity. Oncol. Reports 33:751-7

S.A. Ballendine, Q. Greba, W. Dawicki, X. Zhang, J.R. Gordon, J.G. Howland. 2015.  Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: implications for neurodevelopmental psychiatric disorders. Progress in Neuro-psychopharmacology & Biological Psychiatry 57:155-65

J. Wei, X Chen, Q Li, J Chen, N Khan, B. Wang, J-W Cheng, JR Gordon and F Li. ELR-CXC chemokine antagonism and cisplatin co-treatment additively reduce H22 hepatoma tumor progression and ameliorate cisplatin-induced nephrotoxicity.  2014.  Oncol. Reports 31(4):1599-604

M. Du, Q Qiu, A Gruslin, JR Gordon, M He, CC Chan, D Li, BK Sang. 2013. SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro. PLoS One. 2013;8(1):e54572. doi: 10.1371/journal.pone.0054572

J Wei, J Peng, B Wanh, H Qu, S Wang, A Faisal, JW Cheng, JR Gordon, F Li. 2013. CXCR1/CXCR2 antagonism is effective in pulmonary defense against Klebsiella pneumoniae infection. Biomed Res Int. 2013:720975. doi: 10.1155/2013/72097

H. Huang, Dawicki W, Zhang X, and Gordon JR.  2013. Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen.  Journal of Immunology 191:1136-43.

H Huang, W. Dawicki, M. Lu, X. Zhang, and J.R. Gordon.  2013. Requisite roles for MHC II and IL-10 expression for induction of tolerance by regulatory dendritic cells in asthma.  Allergy 68:1126-35.

C. Davidson, M. Asaduzzaman, NG Arizmendi, D. Polley, Y. Wu, J.R. Gordon, M. Hollenberg, L. Cameron and H. Vliagoftis. Proteinase-activated receptor-2 activation participates in allergic sensitization to house dust mite allergens in a murine model. Clinical and Experimental Allergy 43:1274-85.

Reid J, Taylor-Gjevre R, Gjevre J, Skomro R, Cotton D, F Olatunbosun, Fentor M, and Gordon JR.  2013.  Can Gestational Hypertension be modified by treating nocturnal airflow limitation? Journal of Clinical Sleep Medicine 15:311-17

Huang Y, Olson DJ, Gordon JR, Middleton DM, Simko E. 2012.  Plasma protein profiles of neonatal pigs before and after suckling.  Can J Veterinary Research 76:1-7

Nayyar A, Dawicki W, Huang H, Lu M, Zhang X, Gordon JR.  2012. Induction of prolonged asthma tolerance by IL-10-differentiated dendritic cells: differential impact on airway hyperresponsiveness and the Th2 immunoinflammatory response.  J Immunol 189:72-9.

Ahmed KA, Wang L, Munegowda MA, Mulligan SJ, Gordon JR, Griebel P, Xiang J. 2012.  Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling.  J Leukocyte Biology 92:289-300.

Liu X, Peng J, Sun W, Yang S, Deng G, Li F, Cheng JW, Gordon JR. 2012.  G31P, an Antagonist against CXC Chemokine Receptors 1 and 2, Inhibits Growth of Human Prostate Cancer Cells in Nude Mice.  Tohoku J Experimental Medicine 228:147-56.

C. Ebeling, J.R. Gordon and D. Adamko.  2011. Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo.  Molecular Nutrition and Food Research 55:1905-08.

H. Huang, W. Dawicki, X. Zhang, J.R. Town and J.R. Gordon. 2010.  Regulatory dendritic cells induce CD4+CD25+Foxp3+ T regulatory effector cell differentiation from CD4+CD25-Foxp3- precursors. J Immunology 185:5003-10.

M. Lu, X. Zhang, H. Huang, and J.R. Gordon. 2011. Induction of immunologic tolerance with IL-10-differentiated dendritic cells in a mouse model of house dust mite-induced asthma. Allergy 66:612-20.

J. Fox, J.R. Gordon and C.K. Haston.  2011.  Combined CXCR1/CXCR2 antagonism decreases radiation-induced alveolitis in the mouse. Radiation Research 175:657-64.

N.G. Arizmendi, M. Abel, K. Mihara, C. Davidson, D. Polley, A. Nadeem, T. El Mays, B.F. Gilmore, B Walker, J.R. Gordon, M.D. Hollenberg and H. Vliagoftis.  2011.  Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and PAR2 activation.   Journal of Immunology 186:3164-72

J. Cleave, P.J. Willson, J.R. Town, and J.R. Gordon. 2010. Fractionation of swine barn dust and assessment of its impact on the respiratory tract following repeated airway exposure.  J Toxicology and Environmental Health 73:1090-1101

X. Zhao, J.R Town, X. Zhang, F. Li, W. Li, and J.R. Gordon.  2010. Blockade of neutrophil responses in aspiration pneumonia via ELR-CXC chemokine antagonism does not predispose to airway bacterial outgrowth. Pulmonary Pharmacology and Therapeutics 23:22-28. 

R. Vig, J.R. Gordon, B. Thebaud, A. D. Befus, and H. Vliagoftis.  2010. The effect of early-life stress on airway inflammation in adult mice. Neuroimmunomodulation 17:229-39

X. Zhao, J. R. Town, A. Yang, X. Zhang, G. Sawicki, and J.R. Gordon. 2010.  A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury.   Journal of Surgical Research 162:264-73.

X. Li, X Zhang, J Town, B Davis, DW Cockcroft, and JR Gordon. 2010.  Interleukin-10-treated dendritic cells tolerize autologous atopic Th2 cells via induction of regulatory T cells.  American Journal of Respiratory Cellular and Molecular Biology 42:190-99.