George Forsyth

• BSA, MSc, University of Manitoba
• PhD, University of Oklahoma
• Post-doctoral training: North Carolina State University and University of Minnesota

Dr. Forsyth's research interests lie with proteins that affect chloride ion transport through the apical membrane of secretory cells. Expression of the pClCa1 regulatory protein cloned in our laboratory increases apical chloride transport via both calcium-dependent and cAMP-dependent conductance proteins. We have evidence for effects of PClCa1 expression on ion transport activity of both CFTR and ENaC. Our findings in recombinant expression systems have recently been confirmed by others in human clinical studies.

Loewen ME, Bekar LK, Walz W, Forsyth GW, Gabriel SE. 2004. "pCLCA1 lacks inherent chloride channel activity in an epithelial colon carcinoma cell line." Am J Physiol Gastrointest Liver Physiol, 287: G33-G41.

Loewen ME, Smith NS, Hamilton DL, Grahn BH, Forsyth GW. 2003. "CLCA protein and canine retinal pigment epithelial chloride transport." Am J Physiol Cell Physiol, 285: C1314-C1321.