Picture of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Lynn Weber

Lynn Weber Professor, Department of Veterinary Biomedical Sciences

Address
WCVM 1319

Research Area(s)

  • Effect of environmental influences, primarily toxicants and nutritional factors, on the cardiovascular system

Academic Credentials

  • BSc, Pharmacy, University of British Columbia
  • PhD, Pharmacology & Toxicology, University of British Columbia
  • Post-doctoral Fellow, Smooth Muscle Research Group, University of Calgary
  • Post-doctoral Researcher, Zoology, Oklahoma State University

Dr. Weber's main teaching responsibility is VBMS 224 (Veterinary Physiology) which is the core physiology course for veterinary students. The course includes sections of cell biology, muscle and cardiovascular physiology. She also teaches in VBMS 333 (General Pharmacology), covering sections on autonomic, cardiac and diuretic pharmacology. She teaches a graduate course VBMS 855 (Integrative Cardiovascular Physiology & Toxicology) and contributes sections to several other graduate courses in cardiovascular physiology and environmental toxicology.

Research Interests

Dr. Weber's main research focus is on the effect of environmental influences, primarily toxicants and nutritional factors, on the cardiovascular system. In particular, she is interested in the interaction of toxicants with genes via nuclear receptors to produce alterations in development and function of the cardiovascular system in mammals and fish. These are her current research projects:

  • Influence of vitamin D deficiency and excess on cardiovascular health.
  • How glycemic index, obesity and diabetes negatively interact to negatively affect cardiovascular health.
  • Role of polycyclic aromatic hydrocarbons (PAHs) in tobacco smoke-induced vascular dysfunction.
  • Interaction of genes and the environment with the aryl hydrocarbon receptor and fish cardiovascular function.
  • Effects of metal mining effluents on fish larval development and performance.

Publications

Gerger, C.J., Weber, L.P. 2015. Comparison of the acute effects of benzo-a-pyrene on adult zebrafish (Danio rerio) cardiorespiratory function following intraperitoneal injection versus aqueous exposure. Aquatic Toxicology 165, 19-30. DOI 10.1016/j.aquatox.2015.05.008.

Adolphe, J.L., Silver, T.I., Childs, H., Drew, M.D., Weber L.P. 2014. Short-term obesity results in detrimental metabolic and cardiovascular changes that may not be reversed with weight loss. British Journal of Nutrition. 112, 647-656.

Gerger, C.J., Thomas, J.K., Janz, D.M., Weber, L.P. 2015. Affects of acute β-naphthoflavone on cardiorespiratory function and metabolism in adult zebrafish (Danio rerio). Fish Physiology & Biochemistry 41, 289-298 DOI 10.1007/s10695-014-9982-z.

Adolphe, J.L., Drew, M.D., Silver, T.I., Fouhse J., Childs, H., Weber L.P. 2015. Effect of an extruded pea or rice diet on post-prandial insulin responses and cardiovascular health in obese dogs. Journal ofAnimal Physiology & Animal Nutrition DOI: 10.1111/jpn.12275.

Wildemann, T.M., Weber, L.P., Siciliano, S.D. 2015. Combined exposure to lead, inorganic mercury and methylmercury shows deviation from additivity for cardiovascular toxicity in rats.  Journal of Applied ToxicologyDOI 10.1002/jat.3092.

Wildemann, T.M., Mirhosseini, N.M., Siciliano, S.D., Weber, L.P. 2015. Cardiovascular responses to lead are biphasic, while methylmercury, but not inorganic mercury, monotonically increases blood pressure in rats. Toxicology 328, 1-11 DOI 10.1016/j.tox.2014.11.009.

Arcand, S., Sharma, K., Al-Dissi, A.N., Cadete, V.J.J., Sawicki, G., Weber, L.P. 2013. Resveratrol protects against functional impairment and cardiac structural protein degradation induced by second hand smoke exposure. Canadian Journal of Cardiology 29, 1320-1328.