Picture of  Lynn Weber

Lynn Weber Interim Associate Dean, Research and Graduate Studies, WCVM | Professor, Department of Veterinary Biomedical Sciences

Research Area(s)

  • Environmental, nutritional and toxicological influences on metabolism and the cardiovascular system.

Academic Credentials

  • BSc, Pharmacy, University of British Columbia
  • PhD, Pharmacology & Toxicology, University of British Columbia
  • Post-doctoral Fellow, Smooth Muscle Research Group, University of Calgary
  • Post-doctoral Researcher, Zoology, Oklahoma State University

Dr. Weber's teaching is in VBMS 306 (General Pharmacology) covering sections on autonomic, cardiac and diuretic pharmacology. She teaches a graduate course VBMS 855 (Integrative Cardiovascular Physiology & Toxicology) and contributes sections to several other undergraduate and graduate courses in cardiovascular physiology and toxicology.

Research Interests

Dr. Weber's research focus is examining how environmental, nutritional and toxicological factors influence metabolism and the cardiovascular system. Her research includes topics in a wide variety of species, from fish to rodents, pigs, dogs and cats. These are her current or recent research projects:

  • Role of taurine deficiency and amino acid nutritional physiology in canine dilated cardiomyopathy.
  • How glycemic index, obesity and diabetes negatively interact to negatively affect cardiovascular health.
  • Role of polycyclic aromatic hydrocarbons (PAHs) in tobacco smoke-induced vascular dysfunction.
  • Interaction of genes and the environment with the aryl hydrocarbon receptor and fish cardiovascular function.

Publications

Geiger, A.K., Weber, L.P. 2022. Assessing non-protein nitrogen sources in commercial dry dog foods. Translational Animal Science DOI:10.1093/tas/txac009.

Reis, L.G., Morris, T., Quilliam, C., Rodrigues, L.A., Loewen, M.E., Weber, L.P. 2021. The effects of fermentation of low or high tannin fava bean-based diets on glucose response, cardiovascular function, and fecal bile acid excretion during a 28-day feeding period in dogs: comparison with commercial diets with normal vs. high protein. Metabolites 11:878 DOI: g/10.3390/metabo11120878.

Sundarrajan, L., Rajeswari, J.J., Weber, L.P., Unniappan, S. 2021. Nesfatin-1-like peptide is a negative regulator of cardiovascular functions in zebrafish and goldfish. General Comparative Endocrinology 313:113892 DOI.org/10.1016/j.ygcen.2021.113892.

Grimard, C., Mangold-Döring, A., Alharbi, H., Weber, L., Hogan, N., Jones, P.D., Giesy, J.P., Hecker, M., Brinkmann, M. 2021. Toxicokinetic models for bioconcentration of organic contaminants in two life stages of white sturgeon (Acipenser transmontanus). Environmental Science & Technology 55:11590-11600 DOI:org/10.1021/acs.est.0c0686.

Mangold-Döring, A., Grimard, C., Green, D., Petersen, S., Nichols, J., Hogan, N., Weber, L., Hollert, H., Hecker, M., Brinkmann, M. 2021. A novel multi-species toxicokinetic modeling approach in support of chemical risk assessment. Environmental Science & Technology 55:9109-9118 DOI: 10.1021/acs.est.1c02055.

 Sundarrajan, L., Rajeswari, J.J., Weber, L.P., Unniappan, S. 2021. The sympathetic/beta-adrenergic pathway mediates irisin regulation of cardiac functions in zebrafish. Comparative Biochemistry & Physiology, Part A, 259:111016. DOI: org/10.1016/j.cbpa.2021.111016.

Briens, J.M., Subramaniam, M., Kilgour, A., Loewen, M.E., Desai, K.M., Adolphe, J.L., Zatti, K.M., Drew, M.D., Weber, L.P. 2021. Glycemic, insulinemic and methylglyoxal postprandial responses to starches alone or in whole diets in dogs versus cats: Relating the concept of glycemic index to metabolic responses and gene expression. Comparative Biochemistry & Physiology, Part A 257:110973. DOI: 10.1016/j.cbpa.2021.110973.

Quilliam, C., Ren, Y., Morris, T., Ai, Y., Weber, L.P. 2021. The effects of 7 days of feeding pulse-based diets on digestibility, glycemic response and taurine levels in domestic dogs. Frontiers in Veterinary Science 8:654223. DOI: 10.3389/fvets.2021.654223.

Reis, L.G., Morris, T., Quilliam, C., Rodrigues, L.A., Loewen, M.E., Weber, L.P. 2021. The effect of fermentation of high- or low-tannin fava bean on glucose tolerance, body weight, cardiovascular function, and blood parameters in dogs after 7 days of feeding: comparison to commercial diets with normal versus high protein. Frontiers in Veterinary Science 8:653771. DOI:10.3389/fvets.2021.653771.

Kodzhahinchev, V., Shekh, K., Weber, L.P., Niyogi, S. 2021. Interactive effects of cadmium and benzo[a]pyrene in adult zebrafish (Danio rerio) during short-term aqueous co-exposure. Environmental Pollution, 272, 116027, DOI.org/10.1016/j.envpol.2020.116027.