Western College of Veterinary Medicine

Research Area(s)

  • Environmental, nutritional and toxicological influences on metabolism and the cardiovascular system.

Academic Credentials

  • BSc, Pharmacy, University of British Columbia
  • PhD, Pharmacology & Toxicology, University of British Columbia
  • Post-doctoral Fellow, Smooth Muscle Research Group, University of Calgary
  • Post-doctoral Researcher, Zoology, Oklahoma State University

Dr. Weber's teaching is in VBMS 306 (General Pharmacology) covering sections on autonomic, cardiac and diuretic pharmacology and veterinary nutrition in VLAC 315. She teaches a graduate course VBMS 855 (Integrative Cardiovascular Physiology & Toxicology) and contributes sections to several other undergraduate and graduate courses in cardiovascular physiology and toxicology.

Research Interests

Dr. Weber's research focus is examining how environmental, nutritional and toxicological factors influence metabolism and the cardiovascular system. Her research includes topics in a wide variety of species, from fish to rodents, pigs, dogs and cats. These are her current or recent research projects:

  • Role of taurine deficiency and amino acid nutritional physiology in canine dilated cardiomyopathy.
  • How glycemic index, obesity and diabetes negatively interact to negatively affect cardiovascular health. 

The Weber lab is committed to equity, diversity and inclusion by creating a supportive, team work driven environment. We welcome students from all backgrounds to create diversity in viewpoints and are flexible to accomodate differing needs. We use this principal as we work toward a common goal of helping to keep ourselves and our animals safe and healthy.

weber-lab-2020.jpg

Weber lab lunch Feb 2020: (L to R) Chloe Quilliam, Bright Boamah, Lynn Weber, Priscila Curso-Almeida, Luciana Guimaraes-Reis, Tressa Morris

Publications

 

Mahoney, H., Francisco, da S., Roberts, C., Schultz, M., Ji, X., Alcaraz, A.J., Montgomery, D., Selinger, S., Challis, J.K., Geisy, J., Weber, L., Janz, D., Wiseman, S. Hecker, M., Brinkmann, M. 2022. Exposure to the tire rubber-derived contaminant 6PPD-quinone causes mitochondrial dysfunction. Environmental Science & Technology 9:765-771. DOI.org/10.1021/acs.estlett.2c00431.

Brinkmann, M., Montgomery, D., Selinger, S., Miller, J., Stock, E., Alcaraz, A.J., Challis, J.K., Weber, L., Janz, D., Hecker, M., Wiseman, S. 2022. Acute toxicity of the tire rubber-derived chemical 6PPD-quinone to four fishes of commercial, cultural, and ecological importance to North America. Environmental Science & Technology 8, 779-784 DOI:10.1021/acs.estlett.2c00050.

Morton, J., Patton, B., Morse, C., El'Karsh, Z., Rodrigues, L., Mousseau, D., Ferguson, D., Columbus, D., Weber, L., Olver, T. 2022. Altered cerebrovascular regulation in low birth weight swine. Comparative Biochemistry and Physiology – Part A 267, 111163 DOI.org/10.1016/j.cbpa.2022.111163.

Ren, Y., Quilliam, C., Weber, L.P., Warkentin, T.D., Tulbek, M.C., Ai, Y. 2022. Effects of pulse crop varieties and extrusion parameters on the physicochemical properties, in vitro and in vivo starch digestibility of pet foods. Cereal Chemistry 00, 1-15 DOI: 10.1002/cche.10524.

Geiger, A.K., Weber, L.P. 2022. Assessing non-protein nitrogen sources in commercial dry dog foods. Translational Animal Science 6, 1-11 DOI:10.1093/tas/txac009.

Reis, L.G., Morris, T., Quilliam, C., Rodrigues, L.A., Loewen, M.E., Weber, L.P. 2021. The effects of fermentation of low or high tannin fava bean-based diets on glucose response, cardiovascular function, and fecal bile acid excretion during a 28-day feeding period in dogs: comparison with commercial diets with normal vs. high protein. Metabolites 11:878 DOI: g/10.3390/metabo11120878.

Sundarrajan, L., Rajeswari, J.J., Weber, L.P., Unniappan, S. 2021. The sympathetic/beta-adrenergic pathway mediates irisin regulation of cardiac functions in zebrafish. Comparative Biochemistry & Physiology, Part A, 259:111016. DOI: org/10.1016/j.cbpa.2021.111016.

Briens, J.M., Subramaniam, M., Kilgour, A., Loewen, M.E., Desai, K.M., Adolphe, J.L., Zatti, K.M., Drew, M.D., Weber, L.P. 2021. Glycemic, insulinemic and methylglyoxal postprandial responses to starches alone or in whole diets in dogs versus cats: Relating the concept of glycemic index to metabolic responses and gene expression. Comparative Biochemistry & Physiology, Part A 257:110973. DOI: 10.1016/j.cbpa.2021.110973.

Quilliam, C., Ren, Y., Morris, T., Ai, Y., Weber, L.P. 2021. The effects of 7 days of feeding pulse-based diets on digestibility, glycemic response and taurine levels in domestic dogs. Frontiers in Veterinary Science 8:654223. DOI: 10.3389/fvets.2021.654223.

Reis, L.G., Morris, T., Quilliam, C., Rodrigues, L.A., Loewen, M.E., Weber, L.P. 2021. The effect of fermentation of high- or low-tannin fava bean on glucose tolerance, body weight, cardiovascular function, and blood parameters in dogs after 7 days of feeding: comparison to commercial diets with normal versus high protein. Frontiers in Veterinary Science 8:653771. DOI:10.3389/fvets.2021.653771.

Kodzhahinchev, V., Shekh, K., Weber, L.P., Niyogi, S. 2021. Interactive effects of cadmium and benzo[a]pyrene in adult zebrafish (Danio rerio) during short-term aqueous co-exposure. Environmental Pollution, 272, 116027, DOI.org/10.1016/j.envpol.2020.116027.

Quilliam, C., Ren, Y., Morris, T., Ai, Y., Weber, L.P. 2021. The effects of 7 days of feeding pulse-based diets on digestibility, glycemic response and taurine levels in domestic dogs. Frontiers in Veterinary Science 8:654223. DOI: 10.3389/fvets.2021.654223.

Reis, L.G., Morris, T., Quilliam, C., Rodrigues, L.A., Loewen, M.E., Weber, L.P. 2021. The effect of fermentation of high- or low-tannin fava bean on glucose tolerance, body weight, cardiovascular function, and blood parameters in dogs after 7 days of feeding: comparison to commercial diets with normal versus high protein. Frontiers in Veterinary Science 8:653771. DOI:10.3389/fvets.2021.653771.

Kodzhahinchev, V., Shekh, K., Weber, L.P., Niyogi, S. 2021. Interactive effects of cadmium and benzo[a]pyrene in adult zebrafish (Danio rerio) during short-term aqueous co-exposure. Environmental Pollution, 272, 116027, DOI.org/10.1016/j.envpol.2020.116027.