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Western College of Veterinary Medicine

Research Area(s)

  • Infectious diseases of swine

Academic Credentials

  • BA, University of St. Thomas, St. Paul, Minnesota, 1997
  • DVM, University of Minnesota, 2003
  • Residency in Anatomic Pathology, University of Minnesota, 2009
  • PhD, University of Minnesota, 2011

Dr. Detmer teaches undergraduate systemic pathology to second-year veterinary students (VT PA 353), necropsy rotation to fourth-year veterinary students (VINT 580), and graduate mammalian pathology (VT PA 820/821/822/823) to graduate students.

 

Research Interests

Dr. Detmer specializes in molecular and phenotypical characterization of influenza A viruses and her research interests include infectious diseases of swine, particularly influenza A, porcine reproductive and respiratory syndrome (PRRS), and porcine circovirus type 2.
 

Publications

  • Costa, M.O., Ek, C.E., Patterson, M.H., Nosach, R., Detmer, S.E., Fernando, C., PaulMcKenzie, G., van Ravenstein, S., Enns, C.B., Loewen, M.E., Hill, J.E., Harding, J.C.S.  2019.  Subclinical colitis associated with moderately hemolytic Brachyspira strains.  Journal of Swine Health and Production, 27(4): 196-209.

  • Hill, J.E., Detmer, S.E., Fernando, C., Derbawka, S.A., Nosach, R., Harding, J.C.S.  2019.  Retrospective detection of Brachyspira hampsonii in archived colitis cases from western Canadian swine.  Transboundary and Emerging Diseases, 66(1): 381-388.  https://www.doi.org/10.1111/tbed.13032

  • Malgarin, C.M., Nosach, R., Novakovic, P., Suleman, M., Ladinig, A., Detmer, S.E., MacPhee, D.J., Harding, J.C.S.  2019.  Classification of fetal resilience to porcine reproductive and respiratory syndrome (PRRS) based on temporal viral load in late gestation maternal tissues and fetuses.  Virus Research, 260: 151-162.  https://www.doi.org/10.1016/j.virusres.2018.12.002

  • Suleman, M., Malgarin, C.M., Detmer, S.E., Harding, J.C.S., MacPhee, D.J.  2019.  The porcine trophoblast cell line PTr2 is susceptible to porcine reproductive and respiratory syndrome virus-2 infection.  Placenta, 88: 44-51.  https://www.doi.org/10.1016/j.placenta.2019.10.004

  • Novakovic, P., Detmer, S.E., Suleman, M., Malgarin, C.M., MacPhee, D.J., Harding, J.C.S.  2018.  Histologic changes associated with placental separation in gilts infected with porcine reproductive and respiratory syndrome virus.  Veterinary Pathology, 55(4): 521-530.  https://www.doi.org/10.1177/0300985818765067

  • Suleman, M., Novakovic, P., Malgarin, C.M., Detmer, S.E., Harding, J.C.S., MacPhee, D.J.  2018.  Spatiotemporal immunofluorescent evaluation of porcine reproductive and respiratory syndrome virus transmission across the maternal-fetal interface.  Pathogens and Disease, 76(5).  https://www.doi.org/10.1093/femspd/fty060

  • Harding, J.C.S., Ladinig, A., Novakovic, P., Detmer, S.E., Wilkinson, J.M., Yang, T., Lunney, J.K., Plastow, G.S.  2017.  Novel insights into host responses and reproductive pathophysiology of porcine reproductive and respiratory syndrome caused by PRRSV-2.  Veterinary Microbiology, 209: 114-123.  https://www.doi.org/10.1016/j.vetmic.2017.02.019

  • Lung, O., Ohene-Adjei, S., Buchanan, C., Joseph, T., King, R., Erickson, A., Detmer, S., Ambagala, A.  2017.  Multiplex PCR and microarray for detection of swine respiratory pathogens.  Transboundary and Emerging Diseases, 64(3): 834-848.  https://www.doi.org/10.1111/tbed.12449

  • Nelson, M.I., Culhane, M.R., Trovão, N.S., Patnayak, D.P., Halpin, R.A., Lin, X., Shilts, M.H., Das, S.R., Detmer, S.E.  2017.  The emergence and evolution of influenza A (H1α) viruses in swine in Canada and the United States.  Journal of General Virology, 98(11): 2663-2675, 924.  https://www.doi.org/10.1099/jgv.0.000924

  • Novakovic, P., Harding, J.C.S., Al-Dissi, A.N., Detmer, S.E.  2017.  Type 2 porcine reproductive and respiratory syndrome virus infection increases apoptosis at the maternal-fetal interface in late gestation pregnant gilts.  PLoS ONE, 12(3): e0173360.  https://www.doi.org/10.1371/journal.pone.0173360

  • Detmer, S.E., Bouljihad, M., Hayden, D.W., Schefers, J.M., Armien, A.  2016.  Fatal pyogranulomatous myocarditis in 10 Boxer puppies.  Journal of Veterinary Diagnostic Investigation, 28(2): 144-149.  https://www.doi.org/10.1177/1040638715626486

  • Novakovic, P., Harding, J.C.S., Al-Dissi, A.N., Ladinig, A., Detmer, S.E.  2016.  Pathologic evaluation of type 2 porcine reproductive and respiratory syndrome virus infection at the maternal-fetal interface of late gestation pregnant gilts.  PLoS ONE, 11(3): e0151198.  https://www.doi.org/10.1371/journal.pone.0151198

  • Novakovic, P., Harding, J.C.S., Ladinig, A., Al-Dissi, A.N., MacPhee, D.J., Detmer, S.E.  2016.  Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus.  Veterinary Research, 47(1): 76.  https://www.doi.org/10.1186/s13567-016-0364-7

  • Ladinig, A., Ashley, C., Detmer, S.E., Wilkinson, J.M., Lunney, J.K., Plastow, G., Harding, J.C.  2015.  Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts. Veterinary Research, 46: 107. https://www.doi.org/10.1186/s13567-015-0251-7

  • Wilkinson, J.M., Gunvaldsen, R.E., Detmer, S.E., Dyck, M.K., Dixon, W.T., Foxcroft, G.R., Plastow, G.S., Harding, J.C.  2015.  Transcriptomic and epigenetic profiling of the lung of influenza-infected pigs: A comparison of different birth weight and susceptibility groups. PLoS One, 10(9): e0138653.  https://www.doi.org/10.1371/journal.pone.0138653

  • Nelson, M.I., Viboud, C., Vincent, A.L., Culhane, M.R., Detmer, S.E., Wentworth, D.E., Rambaut, A., Suchard, M.A., Holmes, E.C., Lemey, P.  2015.  Global migration of influenza A viruses in swine. Nature Communications, 6: 6696.  https://www.doi.org/10.1038/ncomms7696

  • Ladinig, A., Detmer, S.E., Clarke, K., Ashley, C., Rowland, R.R., Lunney, J.K., Harding, J.C.  2015.  Pathogenicity of three type 2 porcine reproductive and respiratory syndrome virus strains in experimentally inoculated pregnant gilts. Virus Research, 203: 24-35. https://www.doi.org/10.1016/j.virusres.2015.03.005

  • Nelson, M.I., Wentworth, D.E., Culhane, M.R., Vincent, A.L., Viboud, C., LaPointe, M.P., Lin, X., Holmes, E.C., Detmer, S.E.  2014.  Introductions and evolution of human-origin seasonal influenza a viruses in multinational swine populations. Journal of Virology, 88(17): 10110-10119. https://www.doi.org/10.1128/JVI.01080-14

  • Costa, M.O., Hill, J.E., Fernando, C., Lemieux, H.D., Detmer, S.E., Rubin, J.E., Harding, J.C.  2014.  Confirmation that "Brachyspira hampsonii" clade I (Canadian strain 30599) causes mucohemorrhagic diarrhea and colitis in experimentally infected pigs. BMC Veterinary Research, 10: 129.  https://www.doi.org/10.1186/1746-6148-10-129

  • Culhane, M.R., Detmer, S.E.  2014.  Sample types, collection, and transport for influenza A viruses of swine. In Spackman E. (ed) Animal Influenza Virus. Methods in Molecular Biology (Methods and Protocols), volume 1161. Humana Press: New York, NY., pp. 259-263. https://www.doi.org/10.1007/978-1-4939-0758-8_21

  • Ladinig, A., Wilkinson, J., Ashley, C., Detmer, S.E., Lunney, J.K., Plastow, G., Harding, J.C.  2014.  Variation in fetal outcome, viral load and ORF5 sequence mutations in a large scale study of phenotypic responses to late gestation exposure to type 2 porcine reproductive and respiratory syndrome virus. PLoS One, 9(4): e96104. https://www.doi.org/10.1371/journal.pone.0096104

  • Detmer, S.E., Gunvaldsen, R.E., Harding, J.C.  2013.  Comparison of influenza A virus infection in high- and low-birth-weight pigs using morphometric analysis.  Influenza and Other Respiratory Viruses, 7(s4): 2-9.  https://www.doi.org/10.1111/irv.12199

  • Rubin, J.E., Harms, N.J., Fernando, C., Soos, C., Detmer, S.E., Harding, J.C., Hill, J.E.  2013.  Isolation and characterization of Brachyspira spp. including "Brachyspira hampsonii" from lesser snow geese (Chen caerulescens caerulescens) in the Canadian Arctic.  Microbial Ecolology, 66(4): 813-822. https://www.doi.org/10.1007/s00248-013-0273-5

  • Detmer, S.E., Gramer, M.R., King, V.L., Mathur, S., Rapp-Gabrielson, V.J.  2013.  In vivo evaluation of vaccine efficacy against challenge with a contemporary field isolate from the α cluster of H1N1 swine influenza virus.  Canadian Journal of Veterinary Research, 77(1): 24-32.

  • Allerson, M., Deen, J., Detmer, S.E., Gramer, M.R., Joo, H.S., Romagosa, A., Torremorell, M.  2013.  The impact of maternally derived immunity on influenza A virus transmission in neonatal pig populations. Vaccine, 31(3): 500-505.  https://www.doi.org/10.1016/j.vaccine.2012.11.023

  • Detmer, S.E., Gramer, M.R., Goyal, S.M., Torremorell, M.  2013.  In vitro characterization of influenza A virus attachment in the upper and lower respiratory tracts of pigs.  Veterinary Pathology, 50(4): 648-658.  https://www.doi.org/10.1177/0300985812467469

  • Nelson, M.I., Detmer, S.E., Wentworth, D.E., Tan, Y., Schwartzbard, A., Halpin, R.A., Stockwell, T.B., Lin, X., Vincent, A.L., Gramer, M.R., Holmes, E.C.  2012.  Genomic reassortment of influenza A virus in North American swine, 1998-2011.  Journal of General Virology, 93(12): 2584-2589. https://www.doi.org/10.1099/vir.0.045930-0

  • Lin, L., Liu, Q., Berube, N., Detmer, S., Zhou, Y.  2012.  5'-triphosphate-short interfering RNA: Potent inhibition of influenza A virus infection by gene silencing and RIG-I activation.  Journal of Virology, 86(19): 10359-10369.  https://www.doi.org/10.1128/JVI.00665-12

  • Detmer, S., Gramer, M., Goyal, S., Torremorell, M., Torrison, J.  2012.  Diagnostics and surveillance for Swine influenza. In Richt, J., Webby, R. (eds) Swine Influenza. Current Topics in Microbiology and Immunology, Volume 370.  Springer, Berlin, Heidelberg.  pp. 85-112.  https://www.doi.org/10.1007/82_2012_220

  • Romagosa, A., Allerson, M., Gramer, M., Joo, H.S., Deen, J., Detmer, S., Torremorell, M.  2011.  Vaccination of influenza a virus decreases transmission rates in pigs. Veterinary Research, 42: 120.  https://www.doi.org/10.1186/1297-9716-42-120

  • Nelsonm, M.I., Lemey, P., Tan, Y., Vincent, A., Lam, T.T., Detmer, S., Viboud, C., Suchard, M.A., Rambaut, A., Holmes, E.C., Gramer, M.  2011.  Spatial dynamics of human-origin H1 influenza A virus in North American swine. PLoS Pathogens, 7(6): e1002077.  https://www.doi.org/10.1371/journal.ppat.1002077

  • Detmer, S.E., Patnayak, D.P., Jiang, Y., Gramer, M.R., Goyal, S.M.  2011.  Detection of Influenza A virus in porcine oral fluid samples.  Journal of Veterinary Diagnostic Investigation, 23(2): 241-247.  https://www.doi.org/10.1177/104063871102300207