Supervisor
Dr. Gurpreet Aulakh, Department of Small Animal Clinical Sciences
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Varanasi, India
Academic Credentials
- BSc (Honors) Biochemistry, University of Delhi, 2020
- MSc Biotechnology, South Asian University, 2022
Research
Ozone exposure triggers neutrophilic lung inflammation and can compromise the alveolar–capillary barrier, impairing pulmonary function. My research investigates how mitochondrial ATP synthase and its inhibitor ATP synthase inhibitory factor 1 (IF1) regulates mitochondrial bioenergetics and ATP signalling to influence neutrophil recruitment, activation, and inflammatory lung injury. Experimental approaches integrate cellular and molecular assays with intravital lung microscopy and synchrotron-based imaging to examine neutrophil behaviour, alveolar barrier integrity, and alveolar contractile dynamics. The overall objective is to elucidate the mechanisms linking cellular energy metabolism to ozone-induced lung inflammation, barrier dysfunction, and tissue recovery, providing a foundation for identifying potential therapeutic targets.