- Vaccinology and immunology
Dr. Gerdts received a DVM in 1994 from Hanover Veterinary School and a German PhD equivalent from the Federal Research Institute for Animal Health, Island of Riems and Hanover Veterinary School, Germany in 1997. A postdoctoral fellowship, funded by the German Research Council, was spent from 1998 to 2000 at VIDO in the area of vaccine discovery and mucosal immunology.
Dr. Gerdts is the Associate Director Research of the Vaccine and Infectious Disease Organization (VIDO) at the University of Saskatchewan.
In 2002, he became a research scientist at VIDO and is currently the program leader of the Neonatal Immunization Program at VIDO and the scientific manager of an international project funded by the Bill and Melinda Gates Foundation. Dr. Gerdts' expertise is in the area of human and livestock vaccines, mucosal immunology, and vaccine delivery and formulation.
Development of neonatal vaccines; innate immunity at the respiratory surfaces (antimicrobial peptides); basic mechanisms of intestinal immunity; lymphocyte trafficking; mucosal immunology; chemokines; enteric infections; and knowledge transfer of basic research into applied clinical research and producers.
Salmon H, Berri M, Gerdts V, Meurens F. 2009. "Humoral and cellular factors of maternal immunity in swine." Developmental and Comparative Immunology. 384-93.
Meurens F, Berri M, Auray G, Melo S, Levast B, Virlogeux-Payant I, Chevaleyre C, Gerdts V, Salmon H. 2009. "Early immune response following Salmonella enterica subspecies enterica serovar Typhimurium infection in porcine jejunal gut loops." Veterinary Research. 5.
Garlapati S, Facci M, Polewicz M, Strom S, Babiuk LA, Mutwiri G, Hancock RE, Elliott MR, Gerdts V. 2009. "Strategies to link innate and adaptive immunity when designing vaccine adjuvants." Veterinary Immunology and Immunopathology. 184-91.
Dar A, Potter A, Tikoo S, Gerdts V, Lai K, Babiuk LA, Mutwiri G. 2009. "CpG-ODNs activate innate immune response that suppresses infectious bronchitis virus replication in chicken embryos." Avian Diseases. Accepted.
Dar A, Potter A, Tikoo S, Gerdts V, Lai K, Babiuk LA, Mutwiri G. 2009. "CpG oligodeoxynucleotides activate innate immune response that suppresses infectious bronchitis virus replication in chicken embryos." Avian Diseases. 261-7.
Potter A, Gerdts V, Littel-van den Hurk SD. 2008. "Veterinary vaccines: alternatives to antibiotics?" Animal Health Research Reviews. 187-99.
Garlapati S, Facci M, Polewicz M, Strom S, Babiuk LA, Mutwiri G, Hancock RE, Elliott MR, Gerdts V. 2008. "Strategies to link innate and adaptive immunity when designing vaccine adjuvants." Veterinary Immunology and Immunopathology.
Elahi S, Thompson DR, Strom S, O'Connor B, Babiuk LA, Gerdts V. 2008. "Infection with Bordetella parapertussis but not Bordetella pertussis causes pertussis-like disease in older pigs." Journal of Infectious Diseases. 384-92.
Elahi S, Holmstrom J, Gerdts V. 2007. "The benefits of using diverse animal models for studying pertussis." Trends in Microbiology. 462-8.
Gerdts V, Littel-van den Hurk SD, Griebel PJ, Babiuk LA. 2007. "Use of animal models in the development of human vaccines." Future Microbiology. 667-75.
Mutwiri G, Gerdts V, Lopez M, Babiuk LA. 2007. "Innate immunity and new adjuvants." Rev Sci Tech. 147-56.
Meurens F, Whale J, Brownlie R, Dybvig T, Thompson DR, Gerdts V. 2007. "Expression of mucosal chemokines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune system." Immunology. 544-55.
Meurens F, Berri M, Whale J, Dybvig T, Strom S, Thompson D, Brownlie R, Townsend HG, Salmon H, Gerdts V. 2006. "Expression of TECK/CCL25 and MEC/CCL28 chemokines and their respective receptors CCR9 and CCR10 in porcine mucosal tissues. Veterinary Immunology and Immunopathology. 313-27.
Gerdts V, Mutwiri GK, Tikoo SK, Babiuk LA. 2006. "Mucosal delivery of vaccines in domestic animals." Veterinary Research. 487-510.
Elahi S, Buchanan RM, Babiuk LA, Gerdts V. 2006. "Maternal immunity provides protection against pertussis in newborn piglets." Infection and Immunity. 2619-27.
Elahi S, Buchanan RM, Attah-Poku S, Townsend HG, Babiuk LA, Gerdts V. 2006. "The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets." Infection and Immunity. 2338-52.
Elahi S, Brownlie R, Korzeniowski J, Buchanan R, O'Connor B, Peppler MS, Halperin SA, Lee Sf, Babiuk LA, Gerdts V. 2005. "Infection of newborn piglets with Bordetella pertussis: a new model for pertussis." Infection and Immunity. 3636-45.
Gerdts V, Tsang C, Griebel PJ, Babiuk LA. 2004. "DNA vaccination in utero: a new approach to induce protective immunity in the newborn." Vaccine. 1717-27.
Uwiera RR, Gerdts V, Pontarollo R, Babiuk LA, Griebel P. 2002. "Plasmid DNA induces increased lymhocyte trafficking: A specific role for CpG motifs." Cell Immunology. 155-164.
Mutwiri G, Bowersock T, Kidane A, Sanchez M, Gerdts V, Babiuk LA, Griebel P. 2002. "Induction of mucosal immune responses following enteric immunization with antigen delivered in alginate microspheres." Veterinary Immunology and Immunopathology. 269-76.
Gerdts V, Snider M, Brownlie R, Babiuk LA, Griebel PJ. 2002. "Oral DNA vaccination in utero induces mucosal immunity and immune memory in the neonate." Journal of Immunology. 1877-85.
Gerdts V, Uwiera RR, Mutwiri GK, Wilson DJ, Bowersock T, Kidane A, Babiuk LA, Griebel PJ. 2001. "Multiple intestinal 'loops' provide an in vivo model to analyse multiple mucosal immune responses. Journal of Immunological Methods. 19-33.
van Drunen Littel-van den Hurk S, Gerdts V, Loehr BI, Pontarollo R, Rankin R, Uwiera R, Babiuk LA. 2000. "Recent advances in the use of DNA vaccines for the treatment of diseases of farmed animals." Advanced Drug Delivery Reviews. 13-28.
Gerdts V, Babiuk LA, van Drunen Littel-van den Hurk S, Griebel PJ. 2000. "Fetal immunization by a DNA vaccine delivered into the oral cavity." Nature Medicine. 929-32